WFS1

Across TCGA patient cohorts, WFS1 mutation is significantly associated with the RNA expression of many other genes, with 2,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFS1-associated genes across cancer lineages are CDCA2, ERI1, and OIP5. Each is linked with WFS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both WFS1-to-partner and partner-to-WFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by WFS1-low versus WFS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFS1→partner) and Y-score (partner→WFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CDCA2 →	+0.717	+2.813	.004	.001	3	4
STAD	ERI1 →	+0.791	+3.388	<.001	.004	3	4
UCEC	OIP5 →	+0.677	+3.103	.001	<.001	3	4
SKCM	MCM10 →	+0.655	+2.839	.006	.001	3	4
UCEC	UHRF1 →	+0.610	+2.081	.006	.001	3	4
SKCM	SETD3 →	+0.436	+2.851	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,712 associations by consensus.

CDCA2 by WFS1 expression — SKCM

Explore this box plot interactively →