WFS1

Across TCGA cell cohorts, WFS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,377 significant associations in total. BONE shows the largest number of these associations.

The most reproducible WFS1-associated GO terms across cancer lineages are Regulation of ATF6-mediated unfolded protein response, ER-nucleus signaling pathway, and Olfactory behavior. Each is linked with WFS1 in more than 17 cancer types. Because this analysis shows association rather than direction, both WFS1-to-partner and partner-to-WFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of ATF6-mediated unfolded protein response grouped by WFS1-low versus WFS1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WFS1→partner) and Y-score (partner→WFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of ATF6-mediated unfolded protein response →	+0.199	+1.594	<.001	<.001	3	18
OESOPHAGUS	ER-nucleus signaling pathway →	+0.121	+1.156	<.001	<.001	3	17
SOFT_TISSUE	Olfactory behavior →	+0.399	+1.289	.004	<.001	3	17
BLOOD_Myeloma	ER overload response →	+0.190	+1.986	<.001	<.001	3	17
BONE	Endoplasmic reticulum calcium ion homeostasis →	+0.128	+1.237	<.001	<.001	3	17
PANCREAS	Negative regulation of endoplasmic reticulum unfolded protein response →	+0.149	+1.513	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,377 associations by consensus.

Regulation of ATF6-mediated unfolded protein response by WFS1 expression — BLOOD_Myeloma

Explore this box plot interactively →