WFS1

Across TCGA cell cohorts, WFS1 mutation is significantly associated with the RNA expression of many other genes, with 188 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WFS1-associated genes across cancer lineages are OR13C7, OR13C2, and LY6G6F. Each is linked with WFS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFS1-to-partner and partner-to-WFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C7 grouped by WFS1-low versus WFS1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFS1→partner) and Y-score (partner→WFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR13C7 →	+0.039	+4.369	<.001	.008	3	2
OVARY	OR13C2 →	+0.046	+4.228	.009	.006	3	2
LUNG_NSCLC_LUSC	LY6G6F →	+0.036	+4.643	<.001	.008	3	1
SOFT_TISSUE	OTUD6A →	+0.010	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR2L8 →	+0.021	+4.369	<.001	.008	3	1
LUNG_NSCLC_LUAD	LCE2B →	+0.029	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 188 associations by consensus.

OR13C7 by WFS1 expression — SOFT_TISSUE

Explore this box plot interactively →