WFDC9

Across TCGA patient cohorts, WFDC9 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WFDC9-associated genes across cancer lineages are S100A11P8, RN7SL191P, and HAUS1P1. Each is linked with WFDC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC9-to-partner and partner-to-WFDC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100A11P8 grouped by WFDC9-low versus WFDC9-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC9→partner) and Y-score (partner→WFDC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A11P8 →	+0.109	+8.471	<.001	.005	3	2
UCEC	RN7SL191P →	+0.322	+4.081	<.001	<.001	3	2
UCEC	HAUS1P1 →	+0.244	+4.155	<.001	<.001	3	2
SKCM	PMS2P11 →	+0.097	+3.661	<.001	.009	3	1
SKCM	RPL35AP29 →	+0.248	+3.992	<.001	.006	3	1
SKCM	MRPS36P2 →	+0.236	+3.993	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

S100A11P8 by WFDC9 expression — BRCA

Explore this box plot interactively →