WFDC1

Across TCGA cell cohorts, WFDC1 mutation is significantly associated with the mutation status of many other genes, with 299 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible WFDC1-associated genes across cancer lineages are KCNG1, SLC18A1, and HEATR6. Each is linked with WFDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WFDC1-to-partner and partner-to-WFDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNG1 grouped by WFDC1-low versus WFDC1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WFDC1→partner) and Y-score (partner→WFDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KCNG1 →	+4.824	+5.392	.004	.004	1	2
SKIN	SLC18A1 →	+4.239	+5.053	.007	.007	1	2
SKIN	HEATR6 →	+4.239	+5.053	.007	.007	1	2
SKIN	STON1-GTF2A1L →	+5.824	+5.824	.002	.002	1	2
SKIN	KHSRP →	+4.824	+5.392	.004	.004	1	2
LARGE_INTESTINE	ACR →	+4.523	+5.087	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

KCNG1 by WFDC1 expression — SKIN

Explore this box plot interactively →