WEE1

Across TCGA patient cohorts, WEE1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WEE1-associated genes across cancer lineages are 14-3-3_beta, JNK_pT183_Y185, and p62 Lck ligand. Each is linked with WEE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WEE1-to-partner and partner-to-WEE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by WEE1-low versus WEE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WEE1→partner) and Y-score (partner→WEE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.118	-3.143	.009	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.152	-1.986	.045	.032	3	1
UCEC	p62 Lck ligand →	+0.389	+3.459	.008	.005	3	1
UCEC	Akt_pT308 →	+0.660	+2.999	.020	.035	3	1
UCEC	PRAS40_pT246 →	+0.190	+2.013	.014	.018	3	1
UCEC	Rab11 →	-0.150	-3.302	.022	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

14-3-3_beta by WEE1 expression — UCEC

Explore this box plot interactively →