WEE1

Across TCGA cell cohorts, WEE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,319 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WEE1-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Regulation of double-strand break repair via homologous recombination, and Regulation of sister chromatid segregation. Each is linked with WEE1 in more than 15 cancer types. Because this analysis shows association rather than direction, both WEE1-to-partner and partner-to-WEE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by WEE1-low versus WEE1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WEE1→partner) and Y-score (partner→WEE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA integrity checkpoint signaling →	+0.080	+0.758	.008	.001	3	16
BLOOD_Myeloma	Regulation of double-strand break repair via homologous recombination →	+0.086	+1.313	.003	.001	3	15
BONE	Regulation of sister chromatid segregation →	+0.124	+0.833	.003	<.001	3	15
BONE	Epigenetic regulation of gene expression →	+0.083	+0.905	<.001	<.001	3	15
BONE	Centrosome duplication →	+0.095	+0.619	<.001	<.001	3	15
BONE	DNA damage checkpoint signaling →	+0.076	+0.694	.006	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,319 associations by consensus.

DNA integrity checkpoint signaling by WEE1 expression — BONE

Explore this box plot interactively →