WEE1

Across TCGA cell cohorts, WEE1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WEE1-associated genes across cancer lineages are R3HDML, KRTAP4-11, and SLC36A2. Each is linked with WEE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WEE1-to-partner and partner-to-WEE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by WEE1-low versus WEE1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WEE1→partner) and Y-score (partner→WEE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-11 →	+0.045	+5.209	<.001	.005	3	1
BLOOD_Leukemia	SLC36A2 →	+0.011	+3.551	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

R3HDML by WEE1 expression — BLOOD_Lymphoma

Explore this box plot interactively →