WDTC1

Across TCGA cell cohorts, WDTC1 mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDTC1-associated genes across cancer lineages are FGF6, USP17L3, and C9. Each is linked with WDTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDTC1-to-partner and partner-to-WDTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by WDTC1-low versus WDTC1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDTC1→partner) and Y-score (partner→WDTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	FGF6 →	+0.061	+5.000	<.001	.006	3	1
PANCREAS	USP17L3 →	+0.016	+5.000	<.001	.006	3	1
LUNG_SCLC	C9 →	+0.149	+3.256	<.001	.005	3	1
LUNG_SCLC	IL10 →	+0.099	+3.070	.009	.009	3	1
LUNG_SCLC	OR2AJ1 →	+0.048	+3.232	<.001	.008	3	1
BLOOD_Leukemia	AQP8 →	+0.111	+3.474	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

FGF6 by WDTC1 expression — PANCREAS

Explore this box plot interactively →