WDTC1

Across TCGA cell cohorts, WDTC1 mutation is significantly associated with the mutation status of many other genes, with 4,929 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDTC1-associated genes across cancer lineages are MED15, DDX59, and FSIP2. Each is linked with WDTC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both WDTC1-to-partner and partner-to-WDTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED15 grouped by WDTC1-low versus WDTC1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDTC1→partner) and Y-score (partner→WDTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MED15 →	+4.392	+4.392	.009	.009	1	5
BLOOD_Leukemia	DDX59 →	+3.282	+2.814	<.001	<.001	1	5
PANCREAS	FSIP2 →	+3.672	+4.614	.002	.002	1	4
PANCREAS	SIPA1L3 →	+3.257	+4.362	.005	.005	1	4
BLOOD_Lymphoma	USP42 →	+3.832	+4.316	.002	.002	1	4
STOMACH	INO80D →	+4.807	+4.807	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,929 associations by consensus.

MED15 by WDTC1 expression — SKIN

Explore this box plot interactively →