Across TCGA pan-cancer cohorts, WDSUB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WDSUB1 data layer compared with 17 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WDSUB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WDSUB1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where WDSUB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.615	0.256	.007	30	view →
LUAD	OS	Median	III,IV	0.325	0.824	.002	7	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →
HNSC	OS	Median	III,IV	0.848	0.591	.009	4	view →
GBM	DFS	Median	All	0.783	0.654	.014	3	view →
LSCC	OS	Median	II,III,IV	1.000	0.884	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: WDSUB1 tumor-vs-normal RNA expression · all WDSUB1 data types