Across TCGA patient cohorts, WDSUB1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDSUB1-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and EGFR_pY1068. Each is linked with WDSUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDSUB1-to-partner and partner-to-WDSUB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDSUB1→partner) and Y-score (partner→WDSUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.139	+1.807	.018	.027	3	2
UCEC	14-3-3_beta →	-0.118	-3.295	.004	.009	3	1
UCEC	EGFR_pY1068 →	-0.343	-3.000	<.001	.001	3	1
UCEC	eIF4E →	+0.212	+3.013	.014	.018	3	1
UCEC	A-Raf_pS299 →	-0.177	-3.321	<.001	.009	3	1
UCEC	FoxM1 →	+0.213	+1.807	.046	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

WDSUB1 survival (RNA) · tumor vs normal (RNA) · all WDSUB1 data types