WDR90

Across TCGA pan-cancer cohorts, WDR90 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated WDR90 data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher WDR90 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WDR90 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BLCA, KIRC, and UCEC are the cancer types where WDR90 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	III,IV	0.221	0.691	<.001	33	view →
KIRC	OS	Median	All	0.181	0.811	.003	15	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
LGG	DFS	Median	All	0.080	0.826	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.920	0.677	.009	6	view →
SCLC	DFS	Median	All	0.134	0.625	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

WDR90–BLCA (OS)

Open the BLCA breakdown →