WDR89

Across TCGA pan-cancer cohorts, WDR89 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR89 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WDR89 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR89 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and GBM are the cancer types where WDR89 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.882	0.635	.004	19	view →
CCRCC	OS	Quartile	All	1.000	0.614	.028	13	view →
GBM	OS	Median	All	0.601	0.454	.019	5	view →
UCEC	DFS	Quartile	II,III,IV	0.480	0.882	.040	4	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR89–PDAC (DFS)

Open the PDAC breakdown →