WDR89

Across TCGA pan-cancer cohorts, WDR89 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of WDR89’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where WDR89 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types WDR89 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LSCC, LUAD, and HNSC are the cancer types where WDR89 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR89 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.315	<.001	8	view →
LUAD	Female	All	+0.232	<.001	8	view →
HNSC	All	All	+0.101	.005	7	view →
PDAC	All	II,III,IV	−0.293	<.001	6	view →
CCRCC	Male	All	+0.155	<.001	4	view →
COAD	Male	III,IV	+0.640	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

WDR89–LSCC

Open the LSCC breakdown →