WDR89

Across TCGA patient cohorts, WDR89 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR89-associated genes across cancer lineages are FoxM1, JNK2, and Ku80. Each is linked with WDR89 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR89-to-partner and partner-to-WDR89 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by WDR89-low versus WDR89-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR89→partner) and Y-score (partner→WDR89) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.298	+3.009	.022	.019	3	1
UCEC	JNK2 →	+0.345	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.309	+2.335	.009	.020	3	1
UCEC	p90 RSK →	+0.201	+3.472	.036	.002	3	1
UCEC	Rab11 →	-0.174	-3.459	.017	.005	3	1
UCEC	Rad50 →	-0.249	-2.321	.040	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FoxM1 by WDR89 expression — UCEC

Explore this box plot interactively →