Across TCGA pan-cancer cohorts, WDR86 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated WDR86 data layer compared with 2 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher WDR86 RNA is associated with better overall survival. In most high-consensus cancer types, elevated WDR86 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

SKCM, KIRC, and LGG are the cancer types where WDR86 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.804	0.658	<.001	72	view →
KIRC	DFS	Quartile	II,III,IV	0.376	0.665	.002	69	view →
LGG	OS	Median	All	0.933	0.855	<.001	36	view →
LUAD	DFS	Quartile	II,III,IV	0.792	0.592	.002	30	view →
KIRP	DFS	Median	IV	0.038	0.525	.019	28	view →
COAD	OS	Quartile	All	0.689	0.854	.002	26	view →
THCA	DFS	Tertile	All	0.982	0.912	.002	18	view →
ACC	DFS	Tertile	II,III,IV	0.268	0.691	.008	16	view →
ESCA	OS	Median	III,IV	0.570	0.321	.008	15	view →
BRCA	OS	Median	All	0.974	0.950	.015	12	view →
UCEC	DFS	Median	IV	0.824	0.570	.013	12	view →
CESC	DFS	Tertile	All	0.755	0.835	.029	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: WDR86 tumor-vs-normal RNA expression · all WDR86 data types