WDR83

Across TCGA cell cohorts, WDR83 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,478 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDR83-associated GO terms across cancer lineages are Negative regulation of protein localization to chromatin, mRNA cis splicing, via spliceosome, and Spliceosomal tri-snRNP complex assembly. Each is linked with WDR83 in more than 16 cancer types. Because this analysis shows association rather than direction, both WDR83-to-partner and partner-to-WDR83 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to chromatin grouped by WDR83-low versus WDR83-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR83→partner) and Y-score (partner→WDR83) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.148	+0.653	<.001	<.001	3	17
LARGE_INTESTINE	mRNA cis splicing, via spliceosome →	+0.091	+0.672	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Spliceosomal tri-snRNP complex assembly →	+0.098	+0.745	<.001	<.001	3	14
LUNG_SCLC	Spliceosomal conformational changes to generate catalytic conformation →	+0.104	+0.648	<.001	.001	3	14
OESOPHAGUS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.097	+0.629	.001	<.001	2	14
OESOPHAGUS	Electron transport coupled proton transport →	+0.097	+0.629	.001	<.001	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,478 associations by consensus.

Negative regulation of protein localization to chromatin by WDR83 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →