WDR82

Across TCGA patient cohorts, WDR82 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR82-associated genes across cancer lineages are EGFR_pY1068, EGFR, and ERK2. Each is linked with WDR82 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR82-to-partner and partner-to-WDR82 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by WDR82-low versus WDR82-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR82→partner) and Y-score (partner→WDR82) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.310	-3.000	.002	.001	3	1
UCEC	EGFR →	-0.187	-1.807	.004	.027	3	1
UCEC	ERK2 →	+0.213	+1.807	.007	.027	3	1
UCEC	FOXO3a →	-0.099	-3.292	.018	.010	3	1
UCEC	ACC1 →	+0.368	+1.807	.014	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-2.308	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by WDR82 expression — UCEC

Explore this box plot interactively →