WDR81

Across TCGA pan-cancer cohorts, WDR81 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated WDR81 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher WDR81 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WDR81 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

THYM, KIRP, and ESCA are the cancer types where WDR81 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
KIRP	OS	Median	II,III,IV	0.141	0.772	<.001	24	view →
ESCA	OS	Median	All	0.080	0.701	<.001	12	view →
STAD	OS	Median	All	0.098	0.538	.022	9	view →
CESC	DFS	Median	IV	0.053	0.529	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUAD	DFS	Median	II,III,IV	0.221	0.681	.042	3	view →
BLCA	DFS	Median	II,III,IV	0.916	0.607	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

WDR81–THYM (OS)

Open the THYM breakdown →