WDR77

Across TCGA pan-cancer cohorts, WDR77 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WDR77 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher WDR77 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated WDR77 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, UCEC, and PDAC are the cancer types where WDR77 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.858	0.523	.001	35	view →
UCEC	OS	Quartile	All	0.919	1.000	.028	8	view →
PDAC	DFS	Tertile	All	0.527	0.351	.018	6	view →
LUAD	DFS	Quartile	All	0.989	0.832	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WDR77–LSCC (DFS)

Open the LSCC breakdown →