WDR77

Across TCGA patient cohorts, WDR77 mutation is significantly associated with the RNA expression of many other genes, with 473 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR77-associated genes across cancer lineages are MIR4472-1, RNA5SP405, and TRAJ10. Each is linked with WDR77 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR77-to-partner and partner-to-WDR77 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4472-1 grouped by WDR77-low versus WDR77-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR77→partner) and Y-score (partner→WDR77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4472-1 →	+0.615	+5.554	<.001	.004	3	2
UCEC	RNA5SP405 →	+0.306	+3.260	<.001	.004	3	2
UCEC	TRAJ10 →	+0.620	+2.032	<.001	.004	3	2
UCEC	RN7SKP181 →	+0.083	+2.755	.007	.001	3	2
UCEC	RNU6-1149P →	+0.445	+2.935	<.001	<.001	3	2
SKCM	MIR4316 →	+0.493	+4.436	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 473 associations by consensus.

MIR4472-1 by WDR77 expression — LUAD

Explore this box plot interactively →