WDR77

Across TCGA patient cohorts, WDR77 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR77-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with WDR77 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR77-to-partner and partner-to-WDR77 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by WDR77-low versus WDR77-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR77→partner) and Y-score (partner→WDR77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.118	-3.432	.005	.005	3	1
UCEC	eEF2 →	+0.486	+2.999	.001	.035	3	1
UCEC	EGFR_pY1068 →	-0.342	-3.459	.001	.005	3	1
UCEC	A-Raf_pS299 →	-0.139	-3.169	.006	.018	3	1
UCEC	GATA6 →	-0.194	-2.215	.003	.010	3	1
UCEC	ACC1 →	+0.349	+3.013	.023	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

14-3-3_beta by WDR77 expression — UCEC

Explore this box plot interactively →