WDR77

Across TCGA cell cohorts, WDR77 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,993 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WDR77-associated GO terms across cancer lineages are Positive regulation of mRNA splicing, via spliceosome, Maturation of SSU-rRNA, and Telomeric 3' overhang formation. Each is linked with WDR77 in more than 18 cancer types. Because this analysis shows association rather than direction, both WDR77-to-partner and partner-to-WDR77 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA splicing, via spliceosome grouped by WDR77-low versus WDR77-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR77→partner) and Y-score (partner→WDR77) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of mRNA splicing, via spliceosome →	+0.156	+1.026	<.001	.003	3	19
LUNG_SCLC	Maturation of SSU-rRNA →	+0.138	+0.684	<.001	<.001	3	18
BONE	Telomeric 3' overhang formation →	+0.140	+0.897	.001	<.001	3	17
BONE	Ribosome biogenesis →	+0.151	+1.136	<.001	<.001	3	17
URINARY_TRACT	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.170	+1.173	<.001	<.001	3	17
KIDNEY	Positive regulation of mRNA processing →	+0.140	+1.075	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,993 associations by consensus.

Positive regulation of mRNA splicing, via spliceosome by WDR77 expression — URINARY_TRACT

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