WDR73

Across TCGA pan-cancer cohorts, WDR73 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated WDR73 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher WDR73 RNA is associated with better overall survival. In most high-consensus cancer types, elevated WDR73 expression acts as an unfavorable survival marker, although some lineages such as UCS and UCEC show a favorable association.

UCS, LGG, and UVM are the cancer types where WDR73 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	II,III,IV	0.567	0.240	.010	50	view →
LGG	DFS	Median	All	0.767	0.898	<.001	36	view →
UVM	DFS	Quartile	III,IV	0.284	0.798	.012	31	view →
UCEC	OS	Median	III,IV	0.891	0.760	.005	30	view →
READ	OS	Median	II,III,IV	0.847	0.327	.005	29	view →
KICH	DFS	Tertile	III,IV	0.343	1.000	.010	28	view →
OV	DFS	Quartile	All	0.405	0.303	.018	24	view →
LIHC	DFS	Tertile	All	0.328	0.471	.005	21	view →
ESCA	OS	Tertile	IV	0.372	0.743	.024	12	view →
BRCA	OS	Quartile	III,IV	0.880	0.724	.019	11	view →
ACC	DFS	Median	III,IV	0.600	0.093	<.001	11	view →
LUAD	DFS	Median	III,IV	0.279	0.527	.038	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

WDR73–UCS (OS)

Open the UCS breakdown →