WDR72

Across TCGA patient cohorts, WDR72 mutation is significantly associated with the RNA expression of many other genes, with 4,614 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR72-associated genes across cancer lineages are ZWINT, CENPU, and SLBP. Each is linked with WDR72 in more than 4 cancer types. Because this analysis shows association rather than direction, both WDR72-to-partner and partner-to-WDR72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by WDR72-low versus WDR72-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR72→partner) and Y-score (partner→WDR72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.878	+2.432	<.001	<.001	3	5
LUAD	CENPU →	+0.819	+3.357	.004	.005	3	4
UCEC	SLBP →	+0.687	+3.283	<.001	<.001	3	4
UCEC	POC1A →	+0.540	+2.408	.001	<.001	3	4
UCEC	TSR1 →	+0.511	+2.928	<.001	<.001	3	4
UCEC	LETM1 →	+0.552	+2.475	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,614 associations by consensus.

ZWINT by WDR72 expression — UCEC

Explore this box plot interactively →