WDR7

Across TCGA cell cohorts, WDR7 mutation is significantly associated with the RNA expression of many other genes, with 705 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR7-associated genes across cancer lineages are OR5AU1, SULT1C3, and MTRNR2L6. Each is linked with WDR7 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR7-to-partner and partner-to-WDR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by WDR7-low versus WDR7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR7→partner) and Y-score (partner→WDR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR5AU1 →	+0.019	+2.684	<.001	.007	3	2
LARGE_INTESTINE	SULT1C3 →	+0.448	+3.577	.002	.002	3	2
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	2
LUNG_NSCLC_LUAD	GSG1L →	+0.218	+3.470	<.001	.009	3	2
LUNG_NSCLC_LUAD	TP53TG3F →	+0.665	+3.584	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 705 associations by consensus.

OR5AU1 by WDR7 expression — LUNG_SCLC

Explore this box plot interactively →