WDR7

Across TCGA cell cohorts, WDR7 mutation is significantly associated with the mutation status of many other genes, with 6,894 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR7-associated genes across cancer lineages are ARHGEF12, ANKS1B, and SYNGAP1. Each is linked with WDR7 in more than 5 cancer types. Because this analysis shows association rather than direction, both WDR7-to-partner and partner-to-WDR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGEF12 grouped by WDR7-low versus WDR7-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR7→partner) and Y-score (partner→WDR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ARHGEF12 →	+3.337	+2.969	.009	.009	1	6
UPPER_AERODIGESTIVE_TRACT	ANKS1B →	+4.954	+4.392	.008	.008	1	5
BLOOD_Lymphoma	SYNGAP1 →	+3.752	+3.409	<.001	<.001	1	5
SOFT_TISSUE	ADCY1 →	+5.502	+5.502	.003	.003	1	5
SKIN	PLIN4 →	+2.772	+4.604	<.001	<.001	1	5
LARGE_INTESTINE	CACNA1G →	+1.767	+2.450	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,894 associations by consensus.

ARHGEF12 by WDR7 expression — BLOOD_Lymphoma

Explore this box plot interactively →