WDR62

Across TCGA patient cohorts, WDR62 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR62-associated genes across cancer lineages are MSH6, PCNA, and PKC-a_pS657. Each is linked with WDR62 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR62-to-partner and partner-to-WDR62 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by WDR62-low versus WDR62-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR62→partner) and Y-score (partner→WDR62) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MSH6 →	-0.744	-3.433	<.001	.005	3	2
COAD	PCNA →	+0.262	+2.330	.019	.020	3	2
COAD	PKC-a_pS657 →	-0.394	-3.000	.004	.035	3	2
UCEC	Annexin-1 →	+0.517	+2.267	<.001	<.001	3	2
COAD	TSC1 →	-0.539	-3.450	<.001	.005	3	2
COAD	YAP_pS127 →	-0.379	-3.450	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

MSH6 by WDR62 expression — COAD

Explore this box plot interactively →