WDR6

Across TCGA pan-cancer cohorts, WDR6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WDR6 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher WDR6 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where WDR6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	III,IV	0.215	0.868	.006	23	view →
HNSC	DFS	Median	III,IV	0.703	0.864	.006	15	view →
LUAD	OS	Tertile	II,III,IV	0.328	0.866	.011	10	view →
CCRCC	DFS	Quartile	All	0.929	0.693	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

WDR6–PDAC (OS)

Open the PDAC breakdown →