WDR6

Across TCGA pan-cancer cohorts, WDR6 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of WDR6’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where WDR6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types WDR6 is over-expressed in tumor, although a few such as LSCC and CCRCC show the opposite, repressed pattern.

LSCC, CCRCC, and LUAD are the cancer types where WDR6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in WDR6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	−0.145	<.001	6	view →
CCRCC	Male	III,IV	−0.118	.004	6	view →
LUAD	Female	All	−0.148	<.001	5	view →
PDAC	Male	All	−0.266	.009	3	view →
COAD	All	IV	+0.333	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

WDR6–LSCC

Open the LSCC breakdown →