WDR6

Across TCGA patient cohorts, WDR6 mutation is significantly associated with the RNA expression of many other genes, with 4,992 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR6-associated genes across cancer lineages are TVP23B, PFKFB4, and TMCO3. Each is linked with WDR6 in more than 3 cancer types. Because this analysis shows association rather than direction, both WDR6-to-partner and partner-to-WDR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TVP23B grouped by WDR6-low versus WDR6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR6→partner) and Y-score (partner→WDR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TVP23B →	+0.530	+2.508	<.001	.001	3	4
UCEC	PFKFB4 →	+0.541	+1.642	<.001	<.001	3	4
SKCM	TMCO3 →	+0.502	+2.508	.009	.001	3	3
UCEC	TWF1 →	+0.526	+2.137	.001	<.001	3	3
STAD	PIGF →	+0.397	+3.359	.005	.004	3	3
STAD	NEIL2 →	+0.767	+2.618	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,992 associations by consensus.

TVP23B by WDR6 expression — SKCM

Explore this box plot interactively →