WDR6

Across TCGA cell cohorts, WDR6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,217 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDR6-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Regulation of telomere maintenance, and Positive regulation of DNA repair. Each is linked with WDR6 in more than 16 cancer types. Because this analysis shows association rather than direction, both WDR6-to-partner and partner-to-WDR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by WDR6-low versus WDR6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR6→partner) and Y-score (partner→WDR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.090	+0.715	<.001	.002	3	17
BONE	Regulation of telomere maintenance →	+0.094	+1.020	<.001	<.001	3	17
BONE	Positive regulation of DNA repair →	+0.075	+0.745	.001	.007	3	17
LARGE_INTESTINE	Microtubule polymerization →	+0.100	+0.591	<.001	<.001	3	17
BONE	Regulation of DNA repair →	+0.087	+0.982	.001	.001	3	17
BONE	Epigenetic regulation of gene expression →	+0.080	+0.857	.003	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,217 associations by consensus.

Positive regulation of double-strand break repair by WDR6 expression — BONE

Explore this box plot interactively →