WDR6

Across TCGA cell cohorts, WDR6 mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR6-associated genes across cancer lineages are IQCF6, OR2M4, and RHOXF1. Each is linked with WDR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR6-to-partner and partner-to-WDR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF6 grouped by WDR6-low versus WDR6-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR6→partner) and Y-score (partner→WDR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IQCF6 →	+0.070	+5.357	<.001	.003	3	2
BLOOD_Leukemia	OR2M4 →	+0.017	+4.133	.002	.003	3	2
LARGE_INTESTINE	RHOXF1 →	+0.186	+2.470	.001	.004	3	1
LARGE_INTESTINE	FZD3 →	+0.879	+3.364	<.001	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.070	+3.667	.002	<.001	3	1
LARGE_INTESTINE	MTMR4 →	+0.702	+3.364	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

IQCF6 by WDR6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →