Across TCGA patient cohorts, WDR5B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR5B-associated genes across cancer lineages are ASNS, c-Met_pY1235, and EGFR_pY1068. Each is linked with WDR5B in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR5B-to-partner and partner-to-WDR5B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR5B→partner) and Y-score (partner→WDR5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.389	+2.700	.016	.006	3	2
UCEC	c-Met_pY1235 →	+0.072	+3.179	.032	.010	3	2
UCEC	EGFR_pY1068 →	-0.233	-2.321	.040	.033	3	1
UCEC	eIF4E →	+0.209	+2.820	.027	.035	3	1
UCEC	p62 Lck ligand →	+0.474	+2.321	.001	.033	3	1
UCEC	P-Cadherin →	-0.149	-2.999	.021	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

WDR5B survival (RNA) · tumor vs normal (RNA) · all WDR5B data types