WDR54

Across TCGA pan-cancer cohorts, WDR54 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated WDR54 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher WDR54 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR54 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where WDR54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	All	0.793	1.000	.002	12	view →
PDAC	DFS	Tertile	III,IV	0.838	0.297	.007	12	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →
CCRCC	OS	Quartile	All	0.795	1.000	.007	3	view →
LSCC	DFS	Quartile	II,III,IV	0.800	0.950	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

WDR54–UCEC (OS)

Open the UCEC breakdown →