WDR54

Across TCGA patient cohorts, WDR54 mutation is significantly associated with the RNA expression of many other genes, with 927 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR54-associated genes across cancer lineages are OR6C7P, RN7SL435P, and RNU6-675P. Each is linked with WDR54 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR54-to-partner and partner-to-WDR54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C7P grouped by WDR54-low versus WDR54-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR54→partner) and Y-score (partner→WDR54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR6C7P →	+0.048	+4.771	<.001	.006	3	2
SKCM	RN7SL435P →	+0.106	+4.867	<.001	.005	3	2
BLCA	RNU6-675P →	+0.352	+7.640	<.001	.009	3	2
STAD	BPY2DP →	+0.533	+5.105	<.001	.008	3	2
UCEC	RNU6-508P →	+0.360	+3.579	<.001	.002	3	2
HNSC	PLLPP1 →	+0.279	+5.303	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 927 associations by consensus.

OR6C7P by WDR54 expression — SKCM

Explore this box plot interactively →