WDR54

Across TCGA patient cohorts, WDR54 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR54-associated genes across cancer lineages are eIF4E, eIF4G, and ACC1. Each is linked with WDR54 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR54-to-partner and partner-to-WDR54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by WDR54-low versus WDR54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR54→partner) and Y-score (partner→WDR54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.203	+2.459	.046	.020	3	1
UCEC	eIF4G →	+0.326	+2.459	.029	.020	3	1
UCEC	ACC1 →	+0.496	+2.820	.004	.035	3	1
UCEC	Heregulin →	-0.150	-3.584	.011	.002	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.651	+2.459	.008	.020	3	1
UCEC	Notch1 →	+0.167	+3.179	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eIF4E by WDR54 expression — UCEC

Explore this box plot interactively →