WDR54

Across TCGA cell cohorts, WDR54 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,416 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible WDR54-associated GO terms across cancer lineages are Fusion of sperm to egg plasma membrane involved in single fertilization, Protein localization to ciliary transition zone, and Protein localization to cilium. Each is linked with WDR54 in more than 14 cancer types. Because this analysis shows association rather than direction, both WDR54-to-partner and partner-to-WDR54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fusion of sperm to egg plasma membrane involved in single fertilization grouped by WDR54-low versus WDR54-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR54→partner) and Y-score (partner→WDR54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Fusion of sperm to egg plasma membrane involved in single fertilization →	+0.370	+0.588	<.001	.004	3	15
LIVER	Protein localization to ciliary transition zone →	+0.116	+2.092	<.001	<.001	3	13
LIVER	Protein localization to cilium →	+0.095	+2.441	<.001	<.001	3	12
BLOOD_Leukemia	Glycolytic process through fructose-6-phosphate →	+0.104	+1.557	<.001	<.001	3	12
BLOOD_Leukemia	Glycolytic process through glucose-6-phosphate →	+0.104	+1.557	<.001	<.001	3	12
STOMACH	Canonical glycolysis →	+0.129	+1.325	.002	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,416 associations by consensus.

Fusion of sperm to egg plasma membrane involved in single fertilization by WDR54 expression — BLOOD_Myeloma

Explore this box plot interactively →