WDR54

Across TCGA cell cohorts, WDR54 mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible WDR54-associated genes across cancer lineages are LCL161, GSK2801, and AZD5991. Each is linked with WDR54 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR54-to-partner and partner-to-WDR54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by WDR54-low versus WDR54-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR54→partner) and Y-score (partner→WDR54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.513	+2.646	.001	.047	3	1
LARGE_INTESTINE	GSK2801 →	+0.318	+2.649	.046	.046	3	1
LARGE_INTESTINE	AZD5991 →	+0.898	+2.649	.018	.046	3	1
LARGE_INTESTINE	123829 →	+0.590	+2.649	.043	.046	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.613	+2.646	.013	.047	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.286	+2.649	.043	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

LCL161 by WDR54 expression — LARGE_INTESTINE

Explore this box plot interactively →