Across TCGA pan-cancer cohorts, WDR53 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated WDR53 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher WDR53 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated WDR53 expression acts as an unfavorable survival marker.

LUAD, UCEC, and COAD are the cancer types where WDR53 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.111	0.835	<.001	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	II,III,IV	0.074	0.756	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: WDR53 tumor-vs-normal RNA expression · all WDR53 data types