Across TCGA pan-cancer cohorts, WDR53 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated WDR53 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher WDR53 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR53 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

GBM, LSCC, and HNSC are the cancer types where WDR53 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.372	0.691	<.001	21	view →
LSCC	DFS	Quartile	All	0.956	0.653	.006	16	view →
HNSC	DFS	Quartile	II,III,IV	0.903	0.661	.049	1	view →
PDAC	DFS	Quartile	All	0.591	0.973	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: WDR53 tumor-vs-normal RNA expression · all WDR53 data types