Across TCGA patient cohorts, WDR53 protein abundance is significantly associated with the RNA expression of many other genes, with 5,676 significant associations in total. GBM shows the largest number of these associations.

The most reproducible WDR53-associated genes across cancer lineages are SUPT6H, PRKAA2, and C1orf50. Each is linked with WDR53 in more than 2 cancer types. Because this analysis shows association rather than direction, both WDR53-to-partner and partner-to-WDR53 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR53→partner) and Y-score (partner→WDR53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SUPT6H →	-0.600	-0.227	.005	.003	3	2
GBM	PRKAA2 →	-0.673	-0.308	.001	<.001	3	2
GBM	C1orf50 →	-0.367	-0.278	<.001	<.001	3	2
BRCA	VPS37D →	-0.722	-0.180	.008	.007	3	2
BRCA	ZNF763 →	-0.407	-0.218	.002	.001	3	2
GBM	RN7SL531P →	-0.346	-0.233	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,676 associations by consensus.

Exploration

WDR53 survival (RNA) · tumor vs normal (RNA) · all WDR53 data types