Across TCGA patient cohorts, WDR53 mutation is significantly associated with the RNA expression of many other genes, with 2,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR53-associated genes across cancer lineages are OR1D4, RNU6-258P, and RNU1-57P. Each is linked with WDR53 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR53-to-partner and partner-to-WDR53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR53→partner) and Y-score (partner→WDR53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR1D4 →	+0.038	+5.103	.004	.008	3	2
BLCA	RNU6-258P →	+0.383	+7.640	<.001	.009	3	2
STAD	RNU1-57P →	+0.725	+5.026	<.001	.009	3	2
COAD	RNU6-147P →	+0.435	+5.212	.006	.007	3	2
UCEC	HSD17B12 →	+0.600	+3.191	.002	.009	3	1
UCEC	LAMTOR1 →	+0.400	+2.818	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,229 associations by consensus.

Exploration

WDR53 survival (RNA) · tumor vs normal (RNA) · all WDR53 data types