Across TCGA patient cohorts, WDR53 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR53-associated genes across cancer lineages are Ku80, MEK1, and PAI-1. Each is linked with WDR53 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR53-to-partner and partner-to-WDR53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR53→partner) and Y-score (partner→WDR53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.295	+2.335	.013	.020	3	1
UCEC	MEK1 →	+0.383	+3.000	.037	.036	3	1
UCEC	PAI-1 →	+0.351	+3.169	.041	.019	3	1
UCEC	PDCD4 →	-0.505	-2.990	.032	.036	3	1
UCEC	Caspase-8 →	-0.281	-2.321	.026	.035	3	1
UCEC	C-Raf →	+0.205	+2.321	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

WDR53 survival (RNA) · tumor vs normal (RNA) · all WDR53 data types