Across TCGA cell cohorts, WDR53 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible WDR53-associated genes across cancer lineages are OR11A1, PRAMEF4, and BMX. Each is linked with WDR53 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR53-to-partner and partner-to-WDR53 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR53→partner) and Y-score (partner→WDR53) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR11A1 →	+0.018	+4.672	<.001	.002	3	1
BREAST	PRAMEF4 →	+0.027	+4.781	<.001	.003	3	1
BLOOD_Lymphoma	BMX →	+0.713	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	ZIM3 →	+0.005	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	AWAT2 →	+0.027	+4.927	<.001	.001	3	1
BLOOD_Lymphoma	OR1L6 →	+0.022	+4.714	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

WDR53 survival (RNA) · tumor vs normal (RNA) · all WDR53 data types