Across TCGA pan-cancer cohorts, WDR5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated WDR5 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher WDR5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated WDR5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where WDR5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.619	0.800	.009	15	view →
LSCC	DFS	Median	II,III,IV	0.886	0.507	.001	14	view →
CCRCC	DFS	Median	III,IV	0.985	0.144	.008	10	view →
OV	DFS	Median	All	0.874	1.000	.047	4	view →
LUAD	OS	Quartile	All	1.000	0.898	.043	1	view →
GBM	OS	Tertile	All	0.537	0.332	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: WDR5 tumor-vs-normal RNA expression · all WDR5 data types