Across TCGA patient cohorts, WDR5 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,411 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WDR5-associated proteins across cancer lineages are EHMT1, GTF3C4, and RPL12_S38. Each is linked with WDR5 in more than 9 cancer types. Because this analysis shows association rather than direction, both WDR5-to-partner and partner-to-WDR5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR5→partner) and Y-score (partner→WDR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EHMT1 →	+0.373	+0.576	<.001	<.001	3	10
LSCC	GTF3C4 →	+0.431	+0.704	<.001	<.001	3	9
LUAD	RPL12_S38 →	+1.186	+0.675	<.001	<.001	3	8
LSCC	SMC2 →	+0.567	+0.584	<.001	<.001	3	8
GBM	MCM3 →	+0.896	+0.442	<.001	<.001	3	8
GBM	MCM4 →	+0.843	+0.428	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,411 associations by consensus.

Exploration

WDR5 survival (RNA) · tumor vs normal (RNA) · all WDR5 data types