Across TCGA patient cohorts, WDR5 protein abundance is significantly associated with the RNA expression of many other genes, with 19,346 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible WDR5-associated genes across cancer lineages are GTF3C5, CCNB1IP1, and NCOA5. Each is linked with WDR5 in more than 8 cancer types. Because this analysis shows association rather than direction, both WDR5-to-partner and partner-to-WDR5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR5→partner) and Y-score (partner→WDR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GTF3C5 →	+0.630	+0.284	<.001	<.001	3	9
LSCC	CCNB1IP1 →	+0.686	+0.300	<.001	<.001	3	8
HNSC	NCOA5 →	+0.717	+0.288	.009	<.001	3	8
HNSC	TUBGCP3 →	+0.433	+0.120	<.001	.008	3	8
LSCC	TEX10 →	+0.685	+0.315	<.001	<.001	3	8
BRCA	SNAPC4 →	+0.573	+0.165	.005	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,346 associations by consensus.

Exploration

WDR5 survival (RNA) · tumor vs normal (RNA) · all WDR5 data types