Across TCGA patient cohorts, WDR5 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible WDR5-associated genes across cancer lineages are MSH2, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with WDR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both WDR5-to-partner and partner-to-WDR5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (WDR5→partner) and Y-score (partner→WDR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.315	-3.295	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.319	-2.000	.001	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-1.690	.024	.042	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.581	+2.000	.003	.010	3	1
UCEC	IGFBP2 →	-0.761	-2.459	.002	.018	3	1
UCEC	Lck →	+0.164	+2.000	.038	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

WDR5 survival (RNA) · tumor vs normal (RNA) · all WDR5 data types